1) Create a new web application under http://CENTRALADMIN/_admin/WebApplicationList.aspx to host your mysite.
2) Create a site collection unter created web application and choose “My Site Host” under “Template Selection – Enterprise”
3) Define a new path “my” under “Central Admin > Application Managment > Managed Paths”
4) Enable Self-Service Creation for users and set your defined path “my”
5) Define a new permission policy level for site users (Grant – Create Subsites)
6) Grant “Profil” permission for “Everyone”
7) Configure your mysite settings under “Central Administration > Manage Service Application > User Profile Service Application > My Site Settings > Setup My Sites”